TY  - BOOK
AU  - Zhang,Huidong
TI  - DNA Replication - Damage from Environmental Carcinogens
T2  - SpringerBriefs in Biochemistry and Molecular Biology,
SN  - 9789401772129
U1  - 572.84 23
PY  - 2015///
CY  - Dordrecht
PB  - Springer Netherlands, Imprint: Springer
KW  - Cell biology
KW  - Nucleic acids
KW  - Pharmacology
KW  - Nucleic Acid Chemistry
KW  - Cell Biology
KW  - Pharmacology/Toxicology
N1  - DNA replication -- Disturbances of the DNA replication system -- Fate of DNA replisome upon encountering DNA damage -- External Causes for DNA Damage -- Effect of environmental carcinogens on cellular physiology -- Protocols for studies of bypass of DNA damage by DNA polymerase
N2  - This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health
ER  -