3D Analysis of the myocardial microstructure : determination of fiber and sheet orientations /

The master thesis of Johanna Maria Ticar reveals high-resolution insights into the myocardial microstructure and illustrates that cardiac muscle fibers are straight, running in parallel with one preferred fiber direction, however, deposits such as fat seem to compromise the regular and compact structure. Second harmonic generation imaging combined with optical tissue clearing is an accurate method for determining the three-dimensional muscle fiber and sheet orientations and hence, allows the calculation of fiber rotation throughout the ventricle wall. Contents ℓ̐ʼ Structure of the Human Myocardium ℓ̐ʼ Imaging Tools for Fiber Mapping ℓ̐ʼ Optical Tissue Clearing ℓ̐ʼ Second Harmonic Generation Imaging ℓ̐ʼ 3D Reconstruction and Visualization Target Groups ℓ̐ʼ Researchers and Students in the field of Biomedical Engineering with a focus on Bioengineering and℗ℓBiomechanics ℓ̐ʼ Professionals in the field of Biomedicine The Author Johanna Maria Ticar, MSc, studied Biomedical Engineering at Graz University of Technology. Her research interests are the microstructure of the human body, tissue engineering and regenerative medicine, foremost in the field of cardiology